The Immune System Might Have a Special Natural Reaction to COVID-19

Researchers have discovered that four youthful men who experienced serious instances of COVID-19 in the Netherlands had uncommon changes in a similar quality on their X chromosome. The revelation reveals insight into how the immune system presents an early safeguard against the contamination.

Risk Categories

Specialists realize that individuals with conditions, for example, hypertension, diabetes, and obesity, and elderly individuals are at more serious danger of developing a severe form of COVID-19, the sickness brought about by SARS-CoV-2. So when two siblings — both under 35 years of age and healthy — got the infection and required mechanical ventilation in intensive care units in Nijmegen, the Netherlands, scientists presumed that they may share a hereditary weakness.

Specialist’s Opinion

In such a case, you promptly wonder whether hereditary components could be a part of it, according to Alexander Hoischen, a geneticist at Radboud University Medical Center (RUMC) in Nijmegen. Hoischen continued by explaining the fact that it might be a minor occurrence that two siblings from a similar family become so seriously sick. In any case, it is likewise conceivable that an intrinsic mistake of the immune system has assumed a significant role.


Hoischen and his associates were researching this chance when they found two additional siblings with COVID-19 on ventilators at intensive care units somewhere else in Nijmegen. The two people were likewise under 35 years of age. Specialists had admitted the four individuals to the intensive care unit back in the early days of the global pandemic. That happened in March, respectively April 2020. Out of the four that were admitted to the intensive care unit, only three managed to survive.


To recognize any conceivable hereditary weakness to the disease, the scientists sequenced the patients’ genome, which contains the protein-coding portions of the considerable number of qualities in the genome. They focused specifically on qualities that researchers know are engaged with the natural immune reaction.